The results demonstrated that positive parenting mediated the impact of positive perception of parenting on quality of life. This finding implies that positive perception and positive parenting should be encouraged when families with children with developmental disabilities receive care or support.
The results demonstrated that positive parenting mediated the impact of positive perception of parenting on quality of life. This finding implies that positive perception and positive parenting should be encouraged when families with children with developmental disabilities receive care or support.Research suggests exposure to adverse life events is elevated in people with intellectual disabilities. We developed the Lancaster and Northgate Trauma Scales (LANTS) to address the limited availability of screening questionnaires for people with intellectual disabilities affected by adverse traumatic experiences.
The aims of this study were to (i) evaluate the factor structure of the self-report LANTS and (ii) assess compatibility with the International Classification of Diseases Eleventh Revision (ICD-11) criteria for complex PTSD.
Ninety-eight people with mild to moderate intellectual disability (86 % men; mean age 41 years) completed the self-report LANTS. Exploratory factor analysis was undertaken using a polychoric correlation matrix, appropriate for the LANTS ordinal response options.
Seven items including self-harm and anger were non-normal in distribution and excluded from the analysis; a four-factor structure was identified for the 22 remaining items. We make suggestions for correspondence of LANTS items to ICD-11 criteria for complex PTSD.
This is the first exploratory factor analysis of the LANTS. Items pertaining to anger and self-harm may be prone to response bias and development of these items using qualitative methods would be useful. The findings require replication with a larger group of people with intellectual disabilities, including more women.
This is the first exploratory factor analysis of the LANTS. Items pertaining to anger and self-harm may be prone to response bias and development of these items using qualitative methods would be useful. The findings require replication with a larger group of people with intellectual disabilities, including more women.Cellular senescence is an irreversible arrest of cell proliferation triggered by different stimuli, including DNA damage, telomere shortening and oncogenic stress. Senescent cells, by releasing the senescence-associated-secretory-phenotype (SASP), contribute to various diseases pathogenesis. Human atherosclerotic plaque contains cells with multiple markers of senescence that associate with disease severity. We characterized the frequency of senescent cTfh cells and genes expressions before and after treatment with Dasatinib in patients with different degrees of stenosis. Twelve high (?50%), and twelve low ( less then 50%) stenosis patients and six healthy controls were enrolled. The percentage of senescent CD3+CD4+CXCR5+CD153+CD57+ cells was significantly decreased in Dasatinib treated cells from individuals with low and high stenosis (P = 0.0007 and P = 0.0002, respectively). However, the frequency of total lymphocytes, CD3+ and CD4+ T cells were not significantly different between the groups before and after treatment. The expression levels of P53 (P = 0.0003 and P = 0.0001), P16 (P = 0.0005 and P = 0.0002), p21 (P = 0.0002 and P less then 0.0001), SENEX (P = 0.0005 and P less then 0.0001) and BCL-2 (P = 0.0005 and P = 0.0002) were decreased in PBMCs of low and high stenosis groups after treatment with Dasatinib, respectively. The percentage of senescent cTfh cells positively correlated with cholesterol (P = 0.034; r = 0.671), C-reactive protein (CRP) (P = 0.029; r = 0.707), Erythrocyte sedimentation rate (ESR) levels (P = 0.030; r = 0.598) and neutrophil counts (P = 0.021; r = 0.799) in patients with high stenosis. The decreased frequency of senescent cTfh cells and the expression levels of senescence genes after Dasatinib treatment in patients with atherosclerosis suggest a role for Dasatinib in partial clearance or rejuvenation of senescent cTfh cells, which may decrease inflammatory mediators and attenuate disease progression.Microplastics (MPs) pollution has become one of the most severe environmental concerns today. MPs persist in the environment and cause adverse effects in organisms. This review aims to present a state-of-the-art overview of MPs in the aquatic environment. https://www.selleckchem.com/products/pci-32765.html Personal care products, synthetic clothing, air-blasting facilities and drilling fluids from gas-oil industries, raw plastic powders from plastic manufacturing industries, waste plastic products and wastewater treatment plants act as the major sources of MPs. For MPs analysis, pyrolysis-gas chromatography-mass spectrometry (Py-GC-MS), Py-MS methods, Raman spectroscopy, and FT-IR spectroscopy are regarded as the most promising methods for MPs identification and quantification. Due to the large surface area to volume ratio, crystallinity, hydrophobicity and functional groups, MPs can interact with various contaminants such as heavy metals, antibiotics and persistent organic contaminants. Among different physical and biological treatment technologies, the MPs removal performance decreases as membrane bioreactor (&gt; 99%) &gt; activated sludge process (~98%) &gt; rapid sand filtration (~97.1%) &gt; dissolved air floatation (~95%) &gt; electrocoagulation (&gt; 90%) &gt; constructed wetlands (88%). Chemical treatment methods such as coagulation, magnetic separations, Fenton, photo-Fenton and photocatalytic degradation also show moderate to high efficiency of MP removal. Hybrid treatment technologies show the highest removal efficacies of MPs. Finally, future research directions for MPs are elaborated.Pollution of the surrounding habitat poses one of the biggest threats to the coral health and even survival. This study focuses on the occurrence, distribution, bioaccumulation and bioconcentration of polybrominated diphenyl ethers (PBDEs) and phthalate esters (PAEs) in corals, their zooxanthellae and mucus, as well as in their ambient environment in Larak coral reef (Persian Gulf) for the first time. The highest concentrations of the pollutants were recorded in mucus, followed by zooxanthellae, tissue and skeleton. Soft corals with higher lipid content contained more PBDEs and PAEs. Pollutants were both efficiently bioconcentrated from water and bioaccumulated from the ambient sediment, albeit bioconcentration played the most prominent role. Elevated PBDEs and especially PAEs concentrations were detected in the skeletons of the bleached corals if compared to the skeleton samples of the non-bleached individuals.